I-Solid Phase Extraction (SPE) iyisampula yobuchwepheshe bokwelapha ethuthukiswe kusukela maphakathi nawo-1980. Ithuthukiswa inhlanganisela ye-liquid-solid extraction kanye ne-chromatography ewuketshezi. Ikakhulukazi esetshenziselwa ukuhlukaniswa, ukuhlanzwa kanye nokunothisa amasampula. Inhloso eyinhloko ukunciphisa ukuphazamiseka kwesampula ye-matrix nokuthuthukisa ukuzwela kokutholwa.

Ngokusekelwe kumbono we-liquid-solid chromatography, ubuchwepheshe be-SPE busebenzisa i-adsorption ekhethiwe kanye ne-elution ekhethiwe ukuze inothise, ihlukanise futhi ihlanze amasampuli. Kuyinqubo yokukhipha umzimba okuhlanganisa izigaba eziwuketshezi neziqinile; kungase futhi kulinganiswe ngokuthathwa njengenqubo elula ye-chromatographic.
Umdwebo wohlelo lwedivayisi yokukhipha isigaba esiqinile
I-SPE umgomo wokuhlukanisa we-liquid chromatography usebenzisa i-adsorption ekhethiwe kanye ne-elution ekhethiwe. Indlela evame ukusetshenziswa kakhulu ukudlulisa isisombululo sesampula esiwuketshezi nge-adsorbent, ugcine into ezohlolwa, bese usebenzisa isincibilikisi samandla afanele ukukhipha ukungcola, bese ukhipha ngokushesha into ezohlolwa ngenani elincane. i-solvent, ukuze kuzuzwe inhloso yokuhlukana ngokushesha, ukuhlanzwa nokuhlushwa. Kungenzeka futhi ukukhangisa ngokukhetha ukungcola okuphazamisayo futhi uvumele into elinganisiwe iphume; noma ukukhangisa ukungcola kanye nento elinganisiwe ngesikhathi esifanayo, bese usebenzisa isincibilikisi esifanelekile ukuze ukhethe ngokukhetha into elinganisiwe.
I-extractant yendlela yokukhipha isigaba esiqinile iqinile, futhi isimiso sayo sokusebenza sisekelwe eqinisweni lokuthi izingxenye okufanele zilinganiswe kanye nezingxenye eziphazamisayo ezihlala ndawonye kusampula yamanzi zinamandla ahlukene ku-ejenti yokukhipha isigaba esiqinile, ukuze bahlukene omunye komunye. I-ejenti yokukhipha isigaba esiqinile iyisigcwalisi esikhethekile esiqukethe i-C18 noma i-C8, i-nitrile, i-amino namanye amaqembu.