Oligonucleotides waa polymers nucleic acid leh taxane si gaar ah loo qaabeeyey, oo ay ku jiraan antisense oligonucleotides (ASOs), siRNAs (RNA-yada yaryar ee farageliya), microRNAs, iyo aptamers. Oligonucleotides waxaa loo isticmaali karaa in lagu beddelo muujinta hidda-wadaha iyada oo loo marayo habab kala duwan, oo ay ku jiraan RNAi, nabaad-guurka bartilmaameedka iyada oo loo marayo RNase H-dhexdhexaadinta kala-goynta, nidaaminta kala-soocidda, cadaadinta RNA aan codeeyn, firfircoonida hidda-socodka, iyo tafatirka hidda-wadaha.

Inta badan oligonucleotides (ASOs, siRNA, iyo microRNA) waxay isku dhejiyaan si ay u beegsadaan hiddo-wadaha mRNA ama pre-mRNA iyada oo loo marayo isku-dhafka saldhigga ah, iyo aragti ahaan waxay si xushmad leh u habeyn kartaa muujinta hidde-side kasta iyo borotiinka, oo ay ku jiraan kuwo badan oo "aan-daaweyn" ahayn oo la beegsanayo. Aptamers waxay leeyihiin xiriir sare oo loogu talagalay borotiinka la beegsanayo, oo la mid ah qaab dhismeedka saddexaad ee unugyada difaaca jirka, ma aha isku xigxiga. Oligonucleotides ayaa sidoo kale bixiya faa'iidooyin kale, oo ay ku jiraan wax soo saarka fudud iyo farsamooyinka diyaarinta, wareegyada horumarinta gaaban, iyo saameynaha muddada dheer.

Marka la barbardhigo ka-hortagga molecule-yar-yar ee dhaqameed, isticmaalka oligonucleotides sida daroogooyinka waa hab aasaasi ah oo cusub. Awoodda oligonucleotides ee hiddaha saxda ah waxay xoojisay xamaasadda codsiyada daweynta ee kansarka, cudurada wadnaha, iyo cudurrada dhifka ah. Oggolaanshaha dhow ee FDA ee Givosiran, Lumasiran iyo Viltolarsen waxay keenaysaa RNAi, ama daawaynta ku salaysan RNA, ee dhexda u ah horumarinta daroogada.