Tijaabada aashitada nukliyeerka dhab ahaantii waa in lagu ogaado inuu jiro nucleic acid (RNA) ee coronavirus-ka cusub ee jirka mawduuca baaritaanka. Aashitada nucleic ee fayras kasta waxa ku jira ribonucleotides, tirada iyo nidaamka ribonucleotides ee ku jira fayrasyada kala duwana way kala duwan yihiin, taas oo ka dhigaysa mid kasta oo gaar ah.
Aashitada nucleic-ka ee coronavirus-ka cusub sidoo kale waa mid gaar ah, iyo ogaanshaha aashitada nuclei-ka ayaa ah ogaanshaha gaarka ah ee aashitada nucleic ee coronavirus-ka cusub. Ka hor inta aan la baadhin aashitada nuclei-ka, waxa lagama maarmaan ah in la ururiyo muunado laga soo qaado xaakada mawduuca, dhuunta dhuunta, dheecaanka bronchoalveolar lavage fluid, dhiiga iwm. Ogaanshaha cusub ee aashitada nukliyeerka ee coronavirus ayaa caadi ahaan loo isticmaalaa ogaanshaha muunada suufka cunaha. Muunadu waa kala qaybsan tahay oo la nadiifiyaa, waxaana laga soo saaray aashitada nucleic ee cusub ee coronavirus, diyaargarowga tijaabada ayaa diyaar ah.

Ogaanshaha aashitada nukliyeerka ee coronavirus-ka cusub inta badan waxay isticmaashaa tignoolajiyada tirada RT-PCR ee fluorescence, taas oo ah isku darka tignoolajiyada tirada PCR ee fluorescence iyo tignoolajiyada RT-PCR. Habka ogaanshaha, tignoolajiyada RT-PCR waxaa loo isticmaalaa in lagu beddelo nukleic acid (RNA) ee coronavirus-ka cusub una dhigma deoxyribonucleic acid (DNA); dabadeed tignoolajiyada PCR ee tirooyinka fluorescence ayaa loo isticmaalaa in lagu soo koobo DNA-da la helay tiro badan. DNA-da la soo koobay ayaa la ogaadaa waxaana lagu calaamadeeyay baaritaanka galmada. Haddii uu jiro aashito cusub oo coronavirus ah, qalabku wuxuu ogaan karaa calaamadda fluorescent, iyo, sida DNA-gu sii wado inuu soo koobo, calaamada fluorescent ayaa sii kordheysa, sidaas darteed si aan toos ahayn u ogaanaya jiritaanka coronavirus-ka cusub.