Oligonucleotides nucleic acid mapolymers ane zvakanyatsogadzirwa sequences, kusanganisira antisense oligonucleotides (ASOs), siRNAs (madiki anopindira maRNAs), microRNAs, uye aptamers. Oligonucleotides inogona kushandiswa kugadzirisa gene expression kuburikidza nemhando dzakasiyana-siyana, kusanganisira RNAi, chinangwa chekuora kuburikidza neRNase H-mediated cleavage, splicing regulation, noncoding RNA kudzvinyirirwa, gene activation, uye programmed gene editing.

Mazhinji oligonucleotides (ASOs, siRNA, uye microRNA) hybridize kunanga gene mRNA kana pre-mRNA kuburikidza neanopindirana base pairing, uye ne theoretically anogona kusarudza kushandura kutaura kwechero chinangwa gene uye mapuroteni, kusanganisira akawanda "asiri ekurapa" anonangwa. MaAptamers ane hukama hwepamusoro hwepuroteni inonangwa, yakafanana neyepamusoro chimiro chemasoja ekudzivirira chirwere, kwete kutevedzana. Oligonucleotides inopawo mamwe mabhenefiti, anosanganisira ari nyore kugadzira uye nzira dzekugadzirira, kupfupika kwekusimudzira kutenderera, uye mhedzisiro inogara kwenguva refu.

Kuenzaniswa neyechinyakare diki molecule inhibitors, kushandiswa kwe oligonucleotides semishonga inzira yakasarudzika. Iko kugona kweoligonucleotides mune chaiyo genetics kwakawedzera kufarira kwekurapa kwekushandisa mugomarara, chirwere chemoyo, uye zvirwere zvisingawanzo. Zvichangoburwa FDA mvumo yeGivosiran, Lumasiran neViltolarsen inounza RNAi, kana RNA-based therapies, muchikamu chikuru chekugadzirwa kwezvinodhaka.