Oligonucleotides bụ polymers nucleic acid nwere usoro ahaziri ahazi, gụnyere antisense oligonucleotides (ASOs), siRNA (obere RNA na-etinye aka), microRNAs na aptamers. Enwere ike iji oligonucleotides gbanwee mkpụrụ ndụ ihe nketa site na usoro dị iche iche, gụnyere RNAi, nbibi ebumnuche site na RNase H-mediated cleavage, nhazi nhazi, mmegide RNA na-enweghị koodu, ịgbalite mkpụrụ ndụ ihe nketa, na ndezi mkpụrụ ndụ ihe.

Ọtụtụ oligonucleotides (ASOs, siRNA, na microRNA) na-ejikọta iji lekwasịrị anya mkpụrụ ndụ mRNA ma ọ bụ pre-mRNA site na njikọta ntọala, na usoro nwere ike gbanwee okwu nke mkpụrụ ndụ ihe nketa na protein ọ bụla, gụnyere ọtụtụ "na-abụghị ọgwụgwọ" ebumnuche. Aptamers nwere mmekọrịta dị elu maka protein ezubere iche, dị ka usoro nke atọ nke ọgwụ mgbochi, ọ bụghị usoro. Oligonucleotides na-enyekwa uru ndị ọzọ, gụnyere mmepụta na usoro nkwadebe dị mfe, usoro mmepe mkpụmkpụ, na mmetụta na-adịte aka.

E jiri ya tụnyere ndị na-egbochi ụmụ irighiri ihe mgbochi ọdịnala, iji oligonucleotides dị ka ọgwụ bụ ụzọ ọhụrụ dị ọhụrụ. Ike nke oligonucleotides na mkpụrụ ndụ ihe nketa ziri ezi emewo ka ịnụ ọkụ n'obi maka ngwa ọgwụgwọ na ọrịa cancer, ọrịa obi, na ọrịa ndị na-adịghị ahụkebe. Nkwenye FDA na nso nso a maka Givosiran, Lumasiran na Viltolarsen na-eweta RNAi, ma ọ bụ usoro ọgwụgwọ dabere na RNA, n'ime isi mmepe ọgwụ.